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Following single oral doses R , S -lipoic acid (racemic mixture), peak plasma concentrations of R -lipoic acid were found to be 40%-50% higher than S -lipoic acid, suggesting a differential absorption in favor of the R -enantiomer (6, 8, 11)

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Clinical evidence shows that glutathione inhibits the tyrosinase enzyme that produces melanin, but oral absorption is extremely poor, with bioavailability of only 10-20%

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