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In a Phase II trial, patients in the Mazdutide group saw a weight decrease between 5% and 22.5%, with a notable proportion of patients across different dosage groups achieving at least a 10% or even higher degree of weight reduction

The gastric stability is real and documented

10.1080/09513590.2018.1488958 Gynecol Endocrinol

A phase 2 trial of mexiletine, a sodium channel blocker, demonstrated dose-dependent reduction in muscle cramps, though 300 mg doses were associated with fewer adverse events

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Low protein intake during GLP-1 therapy leads to excessive muscle loss relative to fat loss