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Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus under the brand name Mounjaro and for chronic weight management as Zepbound

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Lifestyle changes may be needed All weight loss medications, including Topamax and semaglutide, work best in combination with a lifestyle approach, says Evans, RD