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Meanwhile, as essential metabolites, amino acids are closely associated with immune cell activation and can contribute to tumor immune processes by modulating the function of immune cells
IL-18 can activate intestinal epithelial cells to produce antimicrobial peptides (AMPs) and stimulate the production of Th1, NK and NKT to secrete IFN-, or combine with IL-12 to induce more IL-17-secreting T cells [102, 103]
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Nature 591 , 275280 (2021)
Oral antihistamines: If itching is bothersome, oral non-sedating antihistamines such as cetirizine (10 mg once daily) or loratadine (10 mg once daily) can provide systemic relief
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