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These findings should be considered exploratory and hypothesis-generating rather than confirmatory

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Calcitriol can affect neuroplasticity, apoptosis, and gene expression (such as neurotransmitters, neurotrophic, and synaptic proteins) (102)

6.8.3 Crosstalk with Klotho The Klotho gene is widely recognized to be involved in the anti-aging process in mammals, and under-expression of Klotho is linked to many diseases, including hypertension, diabetes, and chronic kidney disease

10.1038/sj.ijo.0802206 69 KellarD.CraftS

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