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This test evaluates spontaneous alternation behavior, an inherent tendency in rodents to explore a new arm rather than returning to a previously visited one ( 2.6 Y-maze test This test is a widely utilized method for assessing short-term working spatial learning and memory in animals

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Ascorbate can be regenerated from its oxidized forms, monodehydroascorbate (MDHA) and dehydroascorbate (DHA), by MDHA and DHA reductases (MDHARs and DHARs), respectively (Smirnoff, 2018) The activity of DHARs is coupled to oxidation of glutathione, which is also required for spontaneous, non-enzymatic reduction of DHA to ascorbate (Figure 1)

About IGF-1R IGF-1R is a transmembrane receptor tyrosine kinase that plays a central role in regulating cell growth, proliferation, differentiation, and survival, and is involved in both normal development and disease pathophysiology

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The strongest evidence supports the combination approach , which adds another = 7.63 on top