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Rab-mediated cellular trafficking defects are also known to be induced by mutant forms of SOD1, TDP-43, and FUS (Soo et al., 2015

the Young Innovator Association of CAS (Y2022078 to LHZ)

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Many candidates failed to demonstrate meaningful weight loss in the clinic due to potency, selectivity or side effect profiles, leading pharmaceutical companies to dismiss the use of melanocortin compounds for treating general obesity

The utilisation of inhibitors of glutamine metabolism has been demonstrated to promote ROS formation and desensitization in PC cells, consequently resulting in altered cytokine-cytokine receptor interaction pathways, including those involving CCL5, CCR4, LTA, CXCR4, IL-6R and IL-7R, which in turn promote iron death [53]