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Some patients find that adding electrolytes to their water helps, particularly if they experience diarrhea

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Kidney injury appears only as a secondary effect of dehydration from severe gut upset. Anti-drug antibodies form in roughly half to two-thirds of users but do not affect clearance, weight, or blood sugar. Benefits that look like side effects Tirzepatide lowers uric acid (about -0.7 to -1.0 mg/dL, mostly through weight loss) and lowers blood pressure

Whilst these effects might appear complementary, the combined hormonal and metabolic signalling could produce effects that are difficult to monitor or predict without clinical oversight

Richardson agrees

The medication actually validated some of this