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The minor G-allele of the DIO3 variant rs945006 was associated with a protective effect against OA development 105

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In some embodiments, a concentration of the otoprotectant is in a range of about 0.1 mM to about 100 mM, about 1 mM to about 100 mM, about 10 mM to about 100 mM, or about 50 mM to about 100 mM

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