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In fact, we hypothesize that IRAK4 inhibition might be most appropriate in early disease, a strategy that is supported by recent evidence demonstrating that around 40% of terminal bronchioles are already lost in patients with mild COPD (86)

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Determination of plasma CLO concentrations Steady-state plasma CLO concentrations were measured using high-performance liquid chromatographytandem mass spectrometry (HPLC-MS/MS)

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