Studies involving acoustic and chemical insults show that growth factors represent a compelling class of otoprotective compounds (Yagi et al., The HGF mimetic Dihexa is a synthetically derived Angiotensin IV analog that is blood-brain barrier permeable, stable, and orally bioavailable (McCoy et al., in vitro and in vivo , making a strong case for a small molecule activator of HGF/c-Met to confer a neuroprotective benefit (Zhang et al., The experimental value of zebrafish as an animal model for in vivo drug discovery has grown rapidly due to their ease of assessment, large clutch size, and ability to recapitulate human disease conditions (MacRae and Peterson, in vivo , demonstrating that otoprotective drug discovery in zebrafish translates to mammalian systems (Owens et al., In this study, we demonstrate that Dihexa protects lateral line hair cells from aminoglycoside ototoxicity
Epithalon at a Glance According to scientific study based on animal test subjects, Epithalon has been shown to function with telomeres, which are areas of repeating DNA sequences that function to prevent gene degradation near the end of chromosomes
PMID 12418503
Anti-aging & regenerative interest IGF-1 signaling is associated with cellular regeneration and maintenance of tissue integrity
BPC-157 exerts its regenerative effects in part by modulating growth factor pathways, leading to enhanced tissue remodeling and angiogenesis. Sikiric et al., Current Pharmaceutical Design 2
Allergy 77(6):19211923
