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The two drugs in combination haven proven to be highly effective, and since each of these drugs is at a low dose side effects are rare

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I was up to chewing 2 tins a day and after my treatment I have been tobacco free for 6 months now

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Despite these advances, a substantial proportion of patients with melanoma show little response to ICIs, and relapses remain common among those who initially respond ( 3.7 CD47 Cluster of differentiation 47 (CD47) is an immune checkpoint molecule commonly referred to as the dont eat me signal and has attracted substantial attention due to its role in facilitating tumor immune evasion