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This study lasted only six weeks, so well need longer trials to help us really understand whether low-nicotine cigarettes are a safer option for people who are determined to smoke (as many as one in five Americans is a current smoker)

Acknowledgements This work was supported by a Basic Science Research Program grant (NRF-2018R1D1A1B07048778) from the National Research Foundation of Korea

This trend reflects the limitations of Korean e-cigarette regulations, which have been more effective among adolescents with higher SES