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NRT: Although co-administration of varenicline (1 mg twice daily) and transdermal nicotine (21 mg/day) for up to 12 days did not affect nicotine pharmacokinetics, the incidence of adverse reactions was greater for the combination than for NRT alone [see Drug Interactions (7.1)]

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Stimulation of defecation: effects of coffee use and nicotine on rectal tone and visceral sensitivity

1 These traits may occur in combination 2 and can also affect the relationship between adolescent smoking and other risk factors