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In addition to sustained weight loss, long-term use is associated with continued cardiovascular protection, maintained glycemic control, and progressive improvements in metabolic markers

This information can help identify patterns and guide discussions with your healthcare provider about potential adjustments to your treatment plan

This risk is greater for opened multi-dose pens used beyond their in-use period

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Results from the TRIUMPH-4 trial, published in December 2025, showed participants with obesity and knee osteoarthritis taking retatrutide 12mg lost an average of 28.7% of their body weight at 68 weeks

Why where you inject semaglutide matters: Injecting too shallowly (into the dermis) or too deeply (into the muscle) can lead to inconsistent absorption