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Symptoms can include: Tingling or burning in the area Sore throat Oozing and crusting of the blister Fever Headache Painful gums Causes and Risk Factors of Mouth Lesions The exact cause of canker sores is unknown, but possible triggers can include: Grinding or clenching your teeth, especially while sleeping Biting your tongue or chewing your lips Brushing or flossing too vigorously or using a hard toothbrush Drinking hot liquids Minor injury to the mouth due to sharp or broken teeth or braces with protruding wires Food sensitivities, including acidic or spicy foods Hormonal shifts Stress Lack of sleep Vitamin deficiencies Gum disease Sores on the tongue or inside the mouth may be caused or exacerbated by infections, inflammation, and stress

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10.1038/s41419-023-05759-3 221 WangC.YangT.XiaoJ.XuC.AlippeY.SunK.et al (2021)