At 340 Da, GHK-Cu can passively cross intact stratum corneum at low concentrations, but the order-of-magnitude greater dermal load achieved through micro-channel delivery is what the clinical literature on physically enhanced peptide delivery argues for
Exact performance in this context is unknown, however
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These GLP-1R + cells were often accompanied by high expression of Foxp3 and CD25 and low expression of IL-7R (CD127), which were characteristic protein markers of Treg cells