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This effect was likely due to attenuation of spinogenesis promoted by HGF and Dihexa treatments since, without the antagonizing effect of Hinge, each agonist increased mini-AMPA frequencies (Figure 13 A-B and Figure 10) thus forming functional synaptic connections

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While research has shown the peptide can suppress certain tumor markers in some models, the angiogenesis could theoretically support tumor growth in others