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Plant secondary metabolites as modulators of mitochondrial health: an overview of their anti-oxidant
Schisantherin A inhibits cell proliferation by regulating glucose metabolism pathway in hepatocellular carcinoma
July 2324, 2026 The PCAC reviews seven peptides for potential inclusion on the 503A Bulk Drug Substances List
To date, it has been observed that the treatment with this kind of antitumor agents causes ROS generation, mitochondrial dysfunction (including frataxin deficiency, mitochondrial DNA damage and defective components of ETC), loss in antioxidant enzymes, ion channels disturbances and nerve tissue damage (protein carbonylation and lipid peroxidation) (Areti et al., 2013) have described in vitro and in vivo biochemical effects after exposure to high concentrations of oxaliplatin, including neuronal activation of the purinoreceptor subtype 7, ROS and NO production, lipid peroxidation, loss of mitochondrial transmembrane potential and further apoptosis via caspase 3 activation