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The breakthrough nicotine salts formula that made the Juul e-cigarette so addictive and ignited the companys explosive market-share growth made Juul especially attractive to teenagers and other new users who otherwise would never have smoked cigarettes, according to interviews with more than a dozen tobacco researchers, pediatricians, and a Reuters review of Juul patents and independent research on nicotine chemistry

Hiscock et al., 2012)

These antibodies bind with mast cells and trigger the release of a type of protein called histamine from the cells

A Cochrane meta-analysis on 13 clinical studies involving HTPs concluded that there was moderate-certainty evidence that HTP users are exposed to lower levels of HPHCs than smokers

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