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Most parents are confused by side effects versus adjustment reactions that goes along with the use of nutraceuticals and lack the needed background to have confidence their child is a ship sailing in the right direction. The end result being that too many unneeded supplements are given in happenstance fashion or the strategy is abandoned altogether and no improvements are realized

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The effects persisted beyond the peptide's pharmacokinetic half-life, supporting the "trigger" hypothesis (PMID 514474)