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These belong to a class of drugs called incretin mimetics , which either mimic or enhance the effects of gut hormones that regulate appetite and metabolism

When iron metabolism is disordered or ATG expression is abnormal, iron autophagy mediated by NCOA4 can induce ferroptosis by degrading ferritin and inducing iron overload ( Hypoxia can also affect iron metabolism

[46] In 2023, it was the 112th most commonly prescribed medication in the United States, with more than 5 million prescriptions

A randomised non-comparative phase II trial of cixutumumab (IMC-A12) or ramucirumab (IMC-1121B) plus mitoxantrone and prednisone in men with metastatic docetaxel-pretreated castration-resistant prostate cancer