According to the NIH Office of Dietary Supplements, functional B12 deficiency is most commonly seen in patients with one or more of the following: Age over 50 stomach acid production declines with age, and stomach acid is required to free B12 from food PPI or H2 blocker use reflux medications suppress the acid needed for B12 absorption Metformin use, which interferes with B12 absorption directly Vegan or vegetarian diets B12 is found almost exclusively in animal products Gut conditions including celiac, IBS, SIBO, and Crohns MTHFR mutations that affect how B12 is metabolized once absorbed Heavy alcohol use The symptoms of low B12 are easy to dismiss: fatigue, brain fog, low mood, tingling in the hands or feet, weakness, and shortness of breath on mild exertion
The growth hormone secretagogue peptides (CJC-1295, Ipamorelin, GHRP-6) are used in bodybuilding communities partly because elevated HGH supports muscle retention and recovery
The use of PPIs is also thought to contribute to vitamin B12 deficiency (Aroda et al, 2016)
The dose and how often its given should be decided by a doctor based on tests and how the patient is doing
Conditions like pernicious anaemia (an autoimmune disorder where your body cant absorb B12 from food), certain stomach conditions, medications that reduce stomach acid, or even gastrointestinal surgeries (like weight loss surgery) can prevent your body from properly taking in B12, even if youre getting enough in your diet
By upregulating beta-3 adrenergic receptors and directly triggering lipolytic pathways, the peptide can enhance fat mobilization from typically resistant areas
