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Link to the PDF with some thoughts below: fda.gov/media/193343/d The FDA reviewed 5 reports with 109 humans: 24 healthy volunteers rectal 53-person Ulcerative Colitis trial rectal 17 knee-pain patients intra-articular 12 bladder-pain patients intravesical 2 healthy volunteers IVThe FDA has 4 broad reasons against BPC: 1

Because L-5MTHF may contribute to higher nitric oxide levels, hydroxocobalamin may help to maintain normal levels of nitric oxide

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Drugs that usually cannot enter the CNS may become therapeutically beneficial by IN administration, as they bypass the BBB at significantly lower doses, with a subsequent decrease in adverse effects [9]

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