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Under oxidative stress, GSH is oxidized to glutathione disulfide (GSSG), and redox reactions are catalyzed by glutathione peroxidase (GPx) and GSSG reductase 38

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For comparison, in our studies, both Phase-I and Phase-II HSB were fed at satiety and the diet contained 0.56% cysteine [13, 14]

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Future studies with larger datasets may clarify whether specific SNPs disproportionately drive observed effects or if subtle pleiotropic pathways exist