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He became a global sensation as the chain-smoking toddler, with video clips of him puffing excessively on an endless cigarette supply watched by millions around the world

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This study is important for two reasons, Cobb said

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The above damage mechanism can be presented as follows: The particulate matter of micro and nanometer size, heavy metals, radioactive materials, free radicals and peroxidant present in the inhaled cigarette smoke damage the surface of the cell membrane by pitting and etching