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Thus, we proposed that nicotine directly affects the migration of VSMCs from the tunica media to atheromatous plaques in the vascular intima by inducing the transformation from a contractile-type to a synthetic-like type, which occurs before the development of atheromatous plaques

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The most common p53 mutations in human LUAD occur at codon R273, while mutations at R175, which frequently occur in other cancer types, are less common in LUAD [108] (Fig

Longer therapeutic intervals are particularly indicated in patients with psychiatric or other substance use disorders