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The C4 allele demonstrates the strongest association with SZ risk (132)and is closely linked to increased synaptic phagocytosis and elimination by microglia ( Pathogen exposure has long been recognized as a risk factor for the development of schizophrenia (142)

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Common side effects observed in monotherapy trials, similar to other GLP-1 receptor agonists, include gastrointestinal symptoms such as nausea, diarrhea, and vomiting, with most adverse events being mild to moderate in severity