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By targeting both GLP-1 and the Glucose-dependent insulinotropic polypeptide (GIP) receptor, it demonstrated a synergistic effect that surpassed GLP-1 mono-agonists

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Thus, although GIPR in the AP is required for the weight loss effects of GIPR agonists, it is not the target of therapeutic GIPR antagonists, supporting recent findings that Gipr KO in GABAergic neurons also abolished responses to GIPR agonism but not antagonism 6