Dry material: Follow the vial and batch documentation for temperature, moisture, and light protection [13]
Seek prompt medical advice if you experience: Severe or rapidly worsening joint pain that significantly impairs function or mobility A hot, swollen, very painful joint with fever this could indicate septic arthritis requiring SAME-DAY emergency hospital assessment Symptoms of severe allergic reaction after B12 injection (breathing difficulty, facial/tongue swelling, widespread hives, dizziness/collapse) call 999 immediately Systemic symptoms such as unexplained weight loss, night sweats, or profound fatigue Neurological symptoms including weakness, numbness, balance problems, or cognitive changes Symptoms affecting multiple joints simultaneously, particularly if symmetrical (both hands, both knees) Morning stiffness lasting more than 30 minutes , which may suggest inflammatory arthritis Your GP will conduct a thorough clinical assessment, including detailed history-taking and physical examination
Lancet 2023, 402, 720730
In addition to electronic database searches, manual searches were performed using Google Scholar, and the reference lists of all relevant primary and secondary sources were screened to identify additional eligible studies and gray literature
Intramuscular injection causes faster, less controlled absorption leading to increased nausea and side effects within hours
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