Those who answered A lot more severe, A little more severe, or Somewhat more severe were classified as More severe
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The increase in the immature macrophages seen in smokers may be due to the influx of monocyte-derived cells from the peripheral blood, with the additional increase due to AM proliferation within the lung.38 CS exposure and AM immune function Transcriptional profile and inflammation A number of studies have looked at the transcriptional profiles of human AMs isolated from smokers compared with non-smokers.36 47 48 The differential in gene expression belongs to the functional categories of immune/inflammatory response, lysosomal function, antioxidant-related function, signal transduction, regulation of transcription, cell adhesion, ECM and proteinase/anti-proteinase production.48 One such difference was an increase in osteopontin expression in smokers (fourfold), which was confirmed at the protein level and correlated with airflow obstruction
Thompson emerges, snarling, from the Fox and Anchor
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