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10.1093/hmg/ddy009 156 VargasD
A randomised clinical trial published in JAMA Psychiatry (Hendershot et al., April 2025, the first controlled human trial of a GLP-1 for alcohol use disorder), found that semaglutide significantly reduced alcohol craving and the amount consumed during a laboratory drinking procedure, with medium-to-large effect sizes
Cells were kept in charcoal stripped FBS containing DMEM medium for all the treatments
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References Abi-Dargham A, Grace A
The results were striking: Average total weight loss: up to 20.7% of body weight Around one-third of users lost 25% or more of their starting weight Data also showed that semaglutide 7.2mg was well tolerated , with a safety profile consistent with the 2.4mg dose and earlier semaglutide trials from Novo Nordisk This places Wegovy 7.2mg in the same league as Mounjaro 15mg in terms of outcomes
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