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In June 2026 the MHRA approved oral semaglutide, marketed as the Wegovy pill , the first oral GLP-1 receptor agonist licensed in the UK for weight management (distinct from Rybelsus, a lower-dose oral semaglutide licensed for type 2 diabetes)

doi: 10.1007/s10571-020-00947-7 59 ManciniD

In late March 2026, Hims & Hers Health, Inc

Several indirect mechanisms could theoretically link semaglutide use to RLS symptoms, though these remain entirely speculative

Trava offers compounded tirzepatide with B12, not the branded products

Additional factors warranting consideration include active malignancy, recent surgery or trauma, use of oestrogen-containing contraceptives or hormone replacement therapy, smoking, and certain inflammatory conditions such as inflammatory bowel disease