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daily [19], levels of nicotine dependence [38], the heaviness of smoking [39], or cumulative pack years [6], and biomarkers such as cotinine levels [40], suggesting a pharmacologic or neurobiological link between nicotine exposure and mood dysregulation

87 To market a tobacco product that has received an MRTP order, the manufacturer must agree to certain postmarket surveillance and studies that examine consumer perception, behavior, and health pertaining to the product

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These include: Frequency and intensity of nicotine use Type of tobacco or nicotine products used Genetic differences in metabolism Secondhand smoke exposure Passive or environmental exposure Chronic users vs