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In a mouse model of PD, a novel GLP-1R/GIPR dual agonist outperformed single GLP-1R agonist NLY01 in reducing the levels of activated NF-B, TNF-, IL-6, and IL-1, as well as mitigating microglial activation and reactive astrogliosis [93]

For example, TLR4 recognizes bacterial lipopolysaccharides (LPS) and activates the NF-B and interferon pathways, driving proinflammatory cytokine production [54]

Graphical Abstract Highlights Parkinsons disease leads to the loss of dopaminergic neurons and the buildup of -synuclein

This is a positive indicator for BPC-157 safety

Comparable ROIs were applied to the LSEC layer to extract fluorescence values

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