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Two smoking regimes in active regulatory use were employed: namely, ISO 4387 (2000), for ISO smoking conditions (a 35-ml puff of 2 seconds duration taken every 60 seconds with ventilation unobstructed

This can help reduce the risk of developing dependence and mitigate any potential negative health effects

Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD

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3 One study has found that 1 to 1.6 g of total PAHs are detected in the smoke from the average commercial cigarette under standard FTC machine-smoking conditions (see Section 12.5.1 for details about machine smoking conditions)