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According to global market research firm Euromonitor, the annual sales of conventional cigarettes worldwide dropped from approximately 5.96 trillion sticks in 2012 to 5.28 trillion in 2021a decline driven by increasingly stringent smoking regulations around the globe
Also, nicotine stimulates neutrophils to release neutrophil extracellular traps (NETs) in a dose-dependent manner
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Because nicotine is addictive and leads to withdrawal symptoms, it can be hard to stop using ONPs
Population studies cannot tell us whether nicotine itself caused the observed association, whether some other tobacco-related chemical mattered, or whether the finding was partly shaped by who seeks medical care, who receives a diagnosis, and who gets counted in the first place