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The endogenous ligand GIP results in full agonism of the mouse GIPR, and the AMG 133 murine surrogate fully antagonized native GIP (IC 50 = 4.1 nM) (Extended Data Fig

Replace direct comparison language with: How does this compound differ from direct hormone administration models? The answer should state that CJC-1295 / Ipamorelin is studied for upstream receptor pathway research peptide behavior rather than direct hormone replacement

Dumas, M

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A later Molecules paper evaluated growth hormone receptor expression in tendon fibroblasts as a model readout [5]