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128 Since mutant p53 changes immune cell infiltration and phenotypes, we can overexpress TBK1 to reactivate IRF3, which disrupts mutant p53 binding to TBK1 and activates the immune system to suppress tumor growth

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as a result, subcutaneous injections and intranasal delivery are the predominant methods used in research, though both routes present practical challenges for routine clinical use

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At refrigeration temperature (28C), the structure remains stable