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2BD, Supplementary Table 1) is consistent with patients who abuse alcohol and whose cardiac dimensions are relatively unchanged despite disease manifestation during the asymptomatic phase 18

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Fatigue and energy fluctuations Fatigue is a frequently reported side effect, particularly in the first few weeks of treatment and after dose escalations

The impact of oxidative stress is profound, causing damage to lipids, proteins, and DNA, which disrupts cellular function and contributes to disease progression

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