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HF induces a powerful neuro-endocrine activation and causes numerous metabolic alterations that may alter UA production/excretion balance predisposing to hyperuricemia, which may be further aggravated by renal alterations and diuretic use

The PPS plan must include a process for rapid cycle evaluation (RCE) and indicate how it will tie into the states requirement to report to DOH and CMS on a rapid cycle basis

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While originally developed to manage type 2 diabetes, brand-name versions like Wegovy and Zepbound are now fully FDA-approved for chronic weight management