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There are also significant differences among opioids in potency and efficacy, which influence drug choice for various clinical indications and distinguish the safety of various opioids

These include COPD, 46 cystic fibrosis, 47 , 48 influenza infection, 49 and alcoholism, 50 , 51 as ethanol impairs Th1/Th2 balance via GSH depletion 52 (Table 3)