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Diet, absorption, B12/folate function, betaine, mitochondrial ATP, homocysteine, adenosine, creatine demand and toxic burden can all contribute

While renal dysfunction progresses, the most important indicators of oxidative stress are plasma F2-isoprostanes, 8-oxo-7,8-dihydro-2-deoxyguanosine, malondialdehyde (MDA), carbamylated proteins, advanced oxidation protein products, asymmetric dimethylarginine, and oxidized lipoprotein particles (138, 141, 142)

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