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HFpEF exhibits more complexity and has more associated-comorbidities including hypertension compared to HFrEF, and systemic inflammation and its-induced metabolic injury are closely associated with the pathogenesis of HFpEF

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This latest approval of Roxybond fulfills an unmet need for an IR (immediate-release) opioid with abuse-deterrent technology that may reduce misuse and abuse while providing pain relief to medically appropriate patients when used as indicated, Paul Howe, chief commercial officer of Protega, said in a statement

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The protein and gene expression of POMC and NPY in the ARC region also showed the same trend in the three groups (Fig