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doi: 10.1038/383447a0

This biological difference can make weight management more challenging despite best efforts with exercise and diet

Doses used clinically generally start modestly and can be adjusted upward based on the patient, with the intravenous route favored precisely because it sidesteps the oral-absorption question

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Most protocols suggest taking Sermorelin five nights per week rather than seven, allowing periodic receptor recovery that may maintain sensitivity over longer treatment periods

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