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Subsequent studies have also supported the notion that ER stress can lead to impaired mitochondrial fusion, which subsequently affects mitochondrial function in alveolar epithelial cells ( 3.3 Mitochondrial biogenesis in COPD Studies have shown that COPD patients have reduced mitochondrial counts in their lung tissue compared to healthy individuals, likely due to increased cellular death and impaired mitochondrial biogenesis ( 4 Lung cancer Lung cancer accounts for around 11.6% of all cancer cases and is the most prevalent form of cancer globally