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showed that in the emergency department, the circulating concentration of syndecan-1, a marker of glycocalyx degradation, correlates with the fluid requirement, severity of sepsis, extent of organ dysfunction, and risk of mortality, but a direct relationship with glycocalyx degradation has not been identified (123)

The rapid glucose load may also cause blood sugar fluctuations, particularly in patients taking concurrent diabetes medications like insulin or sulfonylureas, which could compound feelings of nausea or discomfort

Lee YI, Choi S, Roh WS, et al

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In this study, while enteritis was not observed in MTX-treated rats, severe appetite loss was