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6 Weight loss and your levothyroxine dose A study in the Journal of Clinical Endocrinology & Metabolism found that lean body mass, not fat mass, is the strongest predictor of your thyroid hormone requirement, which is why your requirement often decreases as you lose weight

doi: 10.1111/jdi.12446 44 NagashimaMWatanabeTTerasakiMTomoyasuMNohtomiKKim-KaneyamaJet al

If obesity worsens after treatment discontinuation, retreatment is generally permitted only after the patient has undergone at least 6 months of an off-treatment period of structured lifestyle interventions equivalent to those required at treatment initiation

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However, the statistical association was strong enough that the studys authors recommended discussing these risks with patients before prescribing GLP-1 medications

As Hemmi notes: Some people will lose access. In an emailed statement to WIRED, a spokesperson for Novo Nordisk says, Moving forward, any compounder that mass produces or sells knockoff drugs is breaking the law and compromising patient safety. A spokesperson for Eli Lilly echoed that sentiment, saying via email that the FDA and a federal court have both made clear that compounders must cease production of compounded tirzepatide knockoffs. Anthony Comuzzie, CEO of the Obesity Society, recognizes that there are legitimate access issues to GLP-1 medications, but he worries that some people who have sought out compounded versions may not meet the medical definition of obesity and are using them more casually for weight loss