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However, a more recent study has described impaired endothelial function even after a single nicotine-free ENDS session that was also accompanied by increased inflammatory mediators (i.e., serum CRP, plasma HMGB1) and oxidative stress [117]
In parallel, the smoking-induced CO binds with haemoglobin and myoglobin, reduces arterial O2 blood saturation, and compromises the efficiency of respiratory enzymes, resulting in dysfunction of the O2 production, transportation and delivery system, especially during exercise