SURMOUNT-1 (Obesity without T2D) The SURMOUNT-1 trial was a landmark study that enrolled 2,539 participants with obesity or overweight (but without T2D) and at least one weight-related comorbidity

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Diarrhea affected 13-16% of patients with diabetes and up to 30% in obesity trials, while vomiting occurred in 5-9% of those treated with tirzepatide for diabetes and up to 24% in obesity studies
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Weight loss outcomes can vary significantly from person to person
Oral glutathiones effects may be slower or inconsistent, while IV glutathione works immediately but requires a clinical setting